It is proton pump inhibitor, acts by inhibiting H+/K+ ATP ase enzyme system and thus blocks final step of acid production and domperidone which is an anti-dopaminergic drug, thus increases gastric motility.combination it is indicated in nausea, vomiting, peptic ulcers Gastric ulcers, duodenal ulcers, NSAID-induced ulcers, zollinger-Elison Syndrome and Gastroesophalgeal reflux disease.