Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicine. Glipizide/Metformin is a sulfonylurea and biguanide antidiabetic combination. The sulfonylurea works by causing the pancreas to release insulin, which helps to lower blood sugar levels. The biguanide decreases the amount of sugar that the liver produces and the intestines absorb, and it also helps to make your body more sensitive to the insulin that you naturally produce.
